NucleoFill Mesotherapy

NucleoFill activates regenerative mechanisms at the cellular level,
improves condition of the skin, firmness, elasticity, colour, texture and radiance.

Preston Skin Medicine and Beauty Clinic, Nucleofil Mesotherapy Skin Boosters Injectables, Product for skin rejuvenation


Face, neck, eye area and décolleté

Procedure Duration

30-60 min


4 treatments every 2-4 weeks


Topical if required

Results last for

4-6 months

Recommended for

Age 28+



Mesotherapy with NucleoFill

activates regenerative mechanisms at the cellular level

A new line of mesotherapy biostimulators based on natural polynucleotides with a triple effect: anti-ageing, lifting, and moisturising. Effective in a wide range of anti-ageing treatments, incl. in anti-ageing prophylaxis, in the loss of skin tension and elasticity, in restoring skin colour and treating tissue atrophy.

Polynucleotides occur in all organisms. They are tiny parts of DNA and RNA nucleic acids. They have the ability to spatially attach to a large number of water molecules, which results in tissue hydration and also helps to rebuild skin cells. They also fight free radicals and inhibit photo and chronic ageing.

NucleoFill activates regenerative mechanisms at the cellular level, giving good results both in terms of the condition of the skin – its firmness or elasticity – and improving its appearance, colour, texture and radiance. The secret of effectiveness, just like the novelty of this formula, is in polynucleotides, polymers of nucleotides. The last ones play an important role as the basic building blocks of nucleic acids (DNA and RNA), and at the same time in the processes of metabolism and signal transmission.

Appearance Improvements Start with a Conversation

Let's talk about your skin problem or PMU concern today

Book a free consultation with me!


Soft Plus

restore youth to the skin around the eyes

The line of luxurious Nucleofill injectables has been expanded with a new product – created especially for the problems and needs of the delicate skin around the eyes. Signs of ageing appearing relatively early in this area are a frequent reason for visits to our studio, which is why we recommend this solution.

Nucleofill Plus Soft mesotherapy is designed for skin bio-restructure. It contains purified polynucleotides of natural origin and rebuilds the natural structure of deep and superficial tissues, restoring the skin around the eyes to a fresh and youthful appearance.

Nucleofill Soft Plus Eyes is a product with ingredients of natural origin, which minimises the risk of allergies. It consists of fragments of highly purified polynucleotide chains (particles of DNA and RNA nucleic acids found in all bodies) with a low molecular weight, making it gentle on the skin but very effective. Nucleofill Soft Plus Eyes is a multifunctional product that works on 3 levels:
  • Action in the dermis and epidermis – by stimulating skin cells, the preparation contributes to the increase in the production of elastin, hyaluronic acid and collagen. This leads to the firmness of the eyelids and gives a strong lifting effect. But that’s not all – Nucleofill Soft Plus Eyes “sweeps away” the free radicals responsible for skin ageing from the tissues, having an antioxidant effect. By binding water in the intercellular space, it provides the skin with long-lasting and in-depth hydration. This improves the quality of the epidermis and skin and visibly reduces wrinkles around the eye.

  • Receptor action (A2) at the vascular level contributes to the improvement of blood flow in skin cells, which reduces the possibility of oedema and accumulation of haemosiderin and thus eliminates dark circles under the eyes. The skin is better vascularised and thus regains its healthy colour.

  • Pleiotropic (multidirectional) action in the subcutaneous tissue – Nucleofill Soft Plus Eyes slows down the degradation of the bone matrix and promotes the homogeneous redistribution of adipose tissue. As a result, deep tissue layers undergo biorestructure. The skeletal system and fatty tissues constitute the “scaffold” for our skin and significantly affect its appearance. Thanks to its in-depth action, Nucleofill Soft Plus Eyes rebuilds the tissues from the inside, supporting the bone matrix and helping to properly distribute fat so that the appearance of the eye area is significantly improved.
Preston Skin Medicine and Beauty Clinic, Nucleofil Mesotherapy Skin Boosters Injectables, Product for skin rejuvenation

NucleoFill Soft Plus Benefits

  • wrinkles and lines around the eyes become shallower
  • tthe skin tone improves, and shadows become less visible
  • the skin of the eyelids is firm and taught
  • the eye area gains a younger, more radiant appearance
  • the skin becomes deeply moisturised
  • the eyebrows rise slightly, which contributes to the effect of rejuvenating the facial features

NucleoFill Soft Plus Indications

Bpermanent Preston PMU Studio & Skin Aesthetics Clinic Logo
  • skin laxity
  • fine wrinkles and “crow’s feet”
  • dark circles under the eyes
  • lowering the browbone
  • pre and post treatment (lifting, blepharoplasty)
  • post treatment (laser resurfacing)
  • Wrinkles and lines around the eyes, including expression lines
  • droopy eyelids
  • loss of firmness and tension in the lower eyelid
  • loss of hydration
  • uneven skin tone


synergy of three mechanisms

Medium & Strong

The synergy of three mechanisms of action restores the skin’s vitality, radiance, and youthful elasticity.

Nucleofill is designated for deep skin renewal and bio-restructuring. This innovative treatment works on three levels: lifting, antioxidation and hydration.

It is a unique, triple action at a cellular level, which gives the effect of clear and long-lasting rejuvenation. Nucleofill is synonymous with innovative biotechnology in aesthetic medicine and anti-ageing.
Preston Skin Medicine and Beauty Clinic, Nucleofil Mesotherapy Skin Boosters Injectables, Product for skin rejuvenation

This scientifically proven method of skin bio stimulation contains polynucleotides that stimulate the skin to rebuild in three ways:


Polynucleotides activate two types of membrane receptors in fibroblasts, thereby stimulating the production of type I collagen as well as glycosaminoglycans, proteins and glycoproteins. The result is lifting and regeneration of the skin, regardless of its type.

Antioxidant Action

In the extracellular space, polynucleotides “scavenge” free radicals, activating a strong antioxidant mechanism.

Deep Hydration

The active ingredients of the product bind to water and ensure permanent iso-osmotic hydration of the extracellular matrix. In this way, they provide the skin with optimal hydration and youthful elasticity.

NucleoFill Medium & Strong Benefits

  • skin lifting and revitalisation
  • stimulation of regenerative mechanisms at the level of cells
  • strengthening of fibroblasts
  • improvement of skin density and cohesiveness
  • improving the appearance and colour of the skin, restoring its glow and radiance

NucleoFill Medium &
Strong Indications

Bpermanent Preston PMU Studio & Skin Aesthetics Clinic Logo
  • hypoxic skin
  • skin exposed to oxidative stress
  • dehydrated skin
  • stretch marks and scars

Before the treatment

  • The treatment does not require any special preparations.
  • The procedure will normally be preceded by an in-depth medical interview.
  • Chemical peels and strong cosmetic products should not be used in the area where the treatment will be performed for a few days before the treatment
  • You should not drink alcohol 48 hours before the procedure
  • Avoid strong heating of the body before the treatment (solarium, saunas, direct sunlight)

After the treatment

  • For 4 days, do not expose yourself to direct sunlight, or warm-up treatments.
  • It is recommended to use SPF 50 sunscreen creams
  • As with most of our cosmetic treatments, we recommend that you avoid vigorous exercise for 7 days following your procedure, we give up using the sauna, swimming pool, gyms, hot baths, solariums, and other places of a large group of people
  • Chemical peels and strong cosmetic products should not be used in the area where the treatment will be performed for a few days after the treatment
  • You should not drink alcohol for 24 hours
  • Make-up should not be done for 48 hours to prevent infection
  • It is important to strictly follow the rules of hygiene: dry your face with disposable towels, tone the skin, keep make-up brushes, and sponges clean, regularly change bath and hand towels, avoid touching your face, replace clean sheets for the post-treatment period.

Possible side effects

  • Mild swelling in the area of application
  • Slight redness and small injection marks
  • Mild bruising due to skin pricking
  • Erythema, itching, irritation
  • All forms of allergic reactions to the products used during the treatment

NucleoFill Before & After


  • below 18 years old
  • pregnancy and lactation period
  • allergy / hypersensitivity to the ingredients of the products
  • hypersensitivity to hyaluronic acid
  • bacterial, fungal, and viral skin infections, skin inflammation
  • active herpes, i.e., viral lesions
  • severe forms of acne requiring pharmacological treatment
  • blood coagulation disorders
  • use of anticoagulant drugs
  • skin allergies
  • high susceptibility to allergies
  • damaged and irritated skin
  • connective tissue diseases
  • tendency to develop hypertrophic scars
  • tendency to develop keloids
  • sunburn
  • discontinuity of the epidermis
  • decompensated diabetes
  • neoplastic and autoimmune diseases
  • use of immunosuppressive drugs
  • use of corticosteroids (6-8 weeks)
  • oral therapy with retinoids, derivatives of vitamin a (at least 6 months break)
  • condition after surgery at the site of surgery (up to 2 months)
  • multiple melanocytic marks, numerous telangiectasias
  • condition after cryotherapy (up to 6 months)
  • skin cancers, including undergoing radiation therapy
  • chemotherapy
  • mental disorders, lack of cooperation
  • oral, long-term steroid therapy
  • psoriasis


The first stage is the production of type I collagen and elastin, which helps to lift and thicken skin tissues. The second stage is the antioxidant effect and elimination of free radicals. The third and final stage is to ensure long-term hydration of skin cells Polymer microparticles: They can act immediately to eliminate free radicals, which are caused by many adverse factors. Among them are mainly long-term and severe stress, polluted air, prolonged sunbathing, poor diet, as well as alcohol abuse and smoking.

Free radicals oxidise fats, including those in the epidermis, which violates the skin’s protective barrier and dries it out. Collagen fibres are damaged and are prone to irritation and wrinkles.

Polynucleotide therapy has a positive effect on the health, condition and colour of the skin, which makes it look beautiful and radiant.
Treatment suitability depends on whether there are any of the above-mentioned contraindications. If not, the answer is simple: treatments containing Nucleofill will come in handy for anyone who thinks that their skin needs support and firmness.

Anyone who wants to achieve a visible rejuvenation effect without interfering with the facial features or wants to reduce the visibility of wrinkles, furrows and lack of firmness in the skin. We also recommend it to people who care about prophylactic anti-ageing effects and those who are exposed to oxidative stress (through air pollution, sun exposure, smoking, poor diet). It is also a good option for anyone with flabby and dehydrated skin.
First, the specialist checks the condition of the skin and on this basis selects the Strong or Medium preparation.Anaesthetic is optional for those who are sensitive to pain, as they might be able to feel unpleasant stimuli that feels like pinching the skin.Then it is injected into the bio-aesthetic points, into the lower and middle parts of the face with 0.15ml of the preparation. It is best to repeat a series of such treatments every 2-4 weeks.

In exceptional cases a combined therapy is required. It is based on injecting a strong dose of the preparation in the middle part of the face and a medium dose in the lower part of the face and neck. This allows the treatment to give the best results possible.

Indications for this type of treatment is primarily dehydrated and under-oxygenated skin, which has lost its elasticity and become dry. Each beauty salon chooses specific products and treatments to best suit the age and specific skin type.
As described above, for better and more long-lasting effects, the treatment should be repeated in 4-6 months. The next visits are decided by the beautician leading the patient.
As a result of the Nucleofill treatment, the skin is introduced to the bio stimulation process. This starts the regenerating process and skin becomes denser and firmer. The antioxidant and moisturising effect make it visibly rejuvenated. Small wrinkles are reduced, the skin becomes radiant and even improves in colour.
The treatment is designed for all people who notice loss of elasticity and signs of ageing, but also those who have problems with skin hydration. The treatment can be used regardless of gender, age, and skin type.

Treat your skin with affordable injectable solution!

Subscribe to our Newsletter

Sign up to receive new treatment updates,
exclusive discounts & more!

2018-2023 © Bpermanent All rights reserved

Scroll to Top
PRP | 3 Sessions £447 £300


£447 £300


£507 £320
PRF | 3 Sessions £447 £300


£447 £300


£270 £180


£240 £170
Nucleofill £180 £150


£180 £150
Lumi Eyes £130 £100


£130 £100
BTX 3 Areas £180 £150


£180 £150
Hurry, before it’s gone!


Are you sure you don't
want to receive a

15% discount?

You can use it on any treatment
booked online!

Just Subscribe
and check your email box!
As simple is that!


Would you like to receive a

15% discount?

You can use it on any treatment
booked online!

Just Subscribe
and check your email box!
As simple is that!


Would you like to receive a

15% discount?

You can use it on any treatment
booked online!

Just Subscribe
and check your email box!
As simple is that!